Just in time for Bowel Cancer Awareness month, I thought I would start off my first blog series on gut health – specifically, the gut microbiome (or gut bacteria).
Did you know that bowel cancer is the second most common type of cancer in Australia? Of all diagnosed cases, 30% of people typically have a family history of the condition. However, apart from genetic factors, recent research has shown that certain microbiota (including in the mouth) may also impact our risk for bowel cancer.
Microbiota are the bacteria living in our digestive tract, from the mouth right down to the rectum. They help to maintain the ‘environment’ in our gut, and humans have an estimated 100 trillion bacteria in the intestine. Different types or amounts of microbiome can cause an imbalanced ‘environment’, and can not only impair digestive function, but may also cause symptoms like constipation, diarrhoea and bloating.
Microbiota help to maintain the ‘environment’ in our gut’, and humans have an estimated 100 trillion bacteria in the intestine.
While we may be born with certain types of microbiome (dependent on genetics and parents’ lifestyle at conception), these gut bacteria regularly change. Diet is something that can greatly influence the types and amounts of bacteria in your gut.
For example, in a study comparing the diets of European children and rural African children, key differences were found with a greater variety of bacteria in the rural African children. These children had a higher biodiversity of gut bacteria, including those related to anti-inflammation and protecting against bowel diseases.
Another review by Yang & Yu compiled the results from several different human and animal studies and found that fibre, protein and fat intake were the main influencers to gut microbiota. The key points were:
- The fermentation of fibre in the large intestine produces short-chain fatty acids (SCFAs), particularly butyrate. This acts as ‘food’ for the cells in the colon and promotes anti-inflammatory actions.
- High intakes of animal protein did not change the variety of microbiota but did cause protein fermentation and bile acid deconjugation, which in turn increased inflammation of the colon.
- Diets high in fat, particularly from processed meats and red meat, increased the release of bile acids, which damaged the lining of the intestines.
- There were conflicting studies on whether processed meat and red meat consumption caused increased risk for developing bowel cancer; however, most of the current evidence suggests that there is an increased risk.
So, it seems like the biodiversity or variety of microbiota is important in helping to reduce the risk of bowel cancer, as is reducing inflammation in the colon. What things can we do to improve the amount and variety of gut bacteria and reduce the risk of inflammation?
Two key methods stood out based on the above research:
Increase fibre intake
Decrease intake of processed and red meats
This post was a nerdy summary of the current scientific evidence in microbiome and bowel cancer. I hope my fellow science nerds enjoyed it. If that’s not you and you feel way in over your head, don’t stress! Over the next few weeks I will be sharing some more simple and practical tips, including how to take the above two methods on board. They will be actionable ways to help you eat your way to a healthier gut!
If you haven’t had enough of the science and still want to learn more, check out the further reading below!
另外，Yang & Yu從許多以人類和動物的研究中收集了不同的結果，發現纖維，蛋白質和脂肪吸收是最主要影響腸道微生物的因素。重要理據包括:
References & Further reading
Bowel Cancer Australia. (2017). About Bowel Cancer. Retrieved from Bowel Cancer Australia: https://www.bowelcanceraustralia.org/what-is-bowel-cancer
Dahmus, J., Kotler, D., Kastenberg, D., & Kistler, C. (2018). The gut microbiome and colorectal cancer: a review of bacterial pathogenesis. Journal of Gastrointestinal Oncology. 9(4):769-777. Accessed from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087872/
Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010). Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proceedings of the National Academy of Sciences of the United States of America.107(33):14691-14696. Accessed from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930426/
Flemer, B., Warren, R., Barret, M., Cisek, K., Das, A., Jeffery, I., Hurley, E., O’Riordain, M., Shanahan, F., & O’Toole, P. (2018). The oral microbiota in colorectal cancer is distinctive and predictive. Gut.67(8). Accessed from https://gut.bmj.com/content/67/8/1454.info
Food and Mood Centre. (2016). Diet and the gut microbiota. Retrieved from https://foodandmoodcentre.com.au/diet-and-the-gut-microbiota/
Yang, J., & Yu, J. (2018). The association of diet, gut microbiota and colorectal cancer: what we eat may imply what we get. Protein & Cell.9(5): 474-487. Accessed from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960467/